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Description

Rippe M, De Backer J, Kutsche K, Mosquera LM, Schler H, Rybczynski M, Bernhardt AM, Keyser B, Hillebrand M, Mir TS, Berger J, Blankenberg S, Koschyk D, von Kodolitsch Y

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doi: 10.1073/pnas.0610266104

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Wipe the surface of the skin, and vial or ampule, with separate alcohol wipes

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neoformans met6 and met3 are both Met auxotrophs, however, the met6 mutant was unable to satisfy this auxotrophy with Cys or Hcy as the sole sulfur source while the met3 could ( met6 , which may impact on other important pathways such as ergosterol biosynthesis

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Down Regulation: the number of receptors decreases (by proteolysis) upon exposure to a high concentration of agonist for a very long time (hours), making the cell less responsive to the same agonist or others that work at the same receptor

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