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Officially, the FDA cites: Insufficient large-scale clinical trials Concerns about consistency, sourcing, and manufacturing standards The need to meet formal drug approval requirements Critics argue (fairly) that this system: Favors large pharmaceutical companies Makes it hard to approve naturally occurring peptides Leaves promising, low-risk compounds in regulatory limbo The short version: This FDA restrictive regulatory change of mind wasnt driven by a sudden safety scare, it was driven by regulatory process and economics

Today 10 , 10411047 (2005)

Part D Genomics Proteomics 49, 101154

Downregulation of GABA receptors triggered by astrocyte activation is a potential mechanism for early inflammation and an increased risk of depression in adulthood [104]

Antimicrobial activity and applications of fermentates from lactic acid bacteria A review