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refer to Methods section), in which we had previously generated quantitative T2-weighted GBCA-uptake brain maps

Commonly, NGF is an upstream regulator of the mTOR pathway and few studies have shown that mTOR can regulate the expression of NGF in cancer cells [22,23,24]

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As a standalone agent and in combination with semaglutide (the CagriSema regimen), it has shown statistically significant reductions in body weight and improvements across multiple cardiometabolic markers

It consists of 42 amino acids that take form after proteolysis of a 153-amino acid precursor

Mechanistic studies suggest that it binds in a manner similar to amylin, affecting cellular signaling and neuroendocrine pathways