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The hBD-3-mediated activation of fibroblasts involves the fibroblast growth factor receptor 1 (FGFR1)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathways, as evidenced by the inhibitory effects of pathway-specific inhibitors as illustrated in Figure 4

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In addition to its localization in the plasma membrane, MRP4 was shown to be found in large amounts in the membrane of dense granules

Thus, our study demonstrates the GPx1-centered signaling module determining cell fate in cancer cells

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Additionally, liver diseases can make hepatocytes more sensitive to injury and compromise the livers regenerative capacity, increasing vulnerability to drug-induced hepatotoxicity