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Peripheral cells may be useful in studying systemic neurochemical changes in ASD

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AIF is not dependent on functional caspases and could, therefore, serve as an alternative death pathway after cellular energy depletion (Broughton et al., Glial Cells and Apoptosis Neurons and cells of the oligodendroglial lineage are the most sensitive cellular elements and are damaged on the front line of ischemia or later they undergo delayed cell death

Mitochondrial dysfunction is often observed in NAFLD patient livers, and our data showed hepatic expression of Ubc13 was significantly downregulated in livers of NAFLD patients analyzed by GeoMx and IHC, further suggesting the role of Ubc13 in mitochondrial functions in NAFLD

have demonstrated that SARS-CoV-2 can cross BBB through the disruption of the basement membrane without the alteration of the tight junction [51]

In contrast, neurons rely for their GSH synthesis on the availability of extracellular cysteine that is provided by astrocytes