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Emerging roles for branched-chain amino acid metabolism in cancer

Ufnal M, Jazwiec R, Dadlez M, Drapala A, Sikora M, Skrzypecki J

Clinical studies show that patients receiving lipotropic injections without dietary restriction see minimal weight change the injections optimise fat metabolism pathways that require mobilised fat (from a caloric deficit) to function effectively

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For macrophages, butyrate can induce metabolic reprogramming towards oxidative phosphorylation and lipid metabolism by upregulating the expression of genes involved in oxidative phosphorylation (such as mitochondrial ATP synthase and NADH dehydrogenase) and lipid metabolism (such as lipoprotein lipase), thereby inducing the polarization of M2 macrophages (Deja et al