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USA 102 , 61956200 (2005)

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79 Evidence implicating the GI microbiota as the site of cyclamate metabolism are numerous: cyclamate was found to be converted to cyclohexamine in vitro by the contents of the lower gut but not by the tissues of rats pretreated with cyclamate

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To elucidate the mode of cell death induced by MG, cells were treated with three inhibitors, and their effects on different modes of cell death were observed (Figure 4D)

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The mGlu4 receptor PAM, foliglurax, failed to improve motor symptoms in PD patients The highly potent and selective mGlu4 receptor PAM, PXT002331/foliglurax, showed a high brain exposure after oral administration 142 , and improved motor symptoms and LIDs in macaques challenged with MPTP 143

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The HDAC inhibitor SAHA can improve PAH by restoring histone acetylation, inducing Treg transformation, and regulating immune-vascular interaction-related genes such as PD-1 and BMPR-2 (Chen et al., 2023)

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Aerts, R

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