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The present invention can be realized like this: L---The application provides a synthetic method of L-glutamic acid-alpha-tert-butyl ester, comprising the following steps: S1L---1S1: reacting L-glutamic acid--methyl ester with a reaction solvent under acid catalysis to generate intermediate 1

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However, in cancer, cells lose their capacity to undergo apoptosis-induced death, which results in unchecked cell proliferation (Morana et al., 2022)

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Regulation of SLC7A11 occurs at both the mRNA and protein levels, primarily involving the transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) and activating transcription factor 4 (ATF4), which positively regulate SLC7A11 ( Beyond the GPx4 pathway, it has been established that certain tumor cells can survive and proliferate despite GPx4 deficiency, owing to compensatory non-GPx4-dependent regulatory pathways