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In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy ( Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )

This study provides a cryoelectron microscopy structure of the 1.7 MDa respiratory supercomplex at near-atomic resolution, revealing the arrangement of complexes I, III and IV and the position of cofactors and phospholipids

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doi: 10.1016/j.cmet.2015.02.009 [DOI] [PMC free article] [PubMed] [Google Scholar] 8