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10.1016/j.clinph.2013.03.006 92 OtalB.DuttaA.Foerster.RipollesO.KuceyeskiA.MirandaP

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AcAc is converted in a reversible reaction catalyzed by D--hydroxybutyrate dehydrogenase (BDH1), leading to the formation of BHB, or undergoes non-enzymatic decarboxylation with the formation of acetone (Figure 2) (104, 105)

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A later randomised trial from the same group reported similar gains, and tellingly, the benefits faded within about 12 weeks of stopping