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The expression of pro-inflammatory cytokines, secretion of Th1, and reduction of expression of anti-inflammatory cytokines suggest that this type of compound must be inducing an immunostimulating response in the infected host

This inflammatory pathway takes part in the expression of pro-inflammatory cytokines, CRP, MMPs, and controls genes, which regulate proliferation, apoptosis, cell adhesion, tissue remodeling, inflammatory processes, immune responses, and cellular-stress responses [38]

SIRT2 inhibited adipogenesis of MSCs by deacetylating FOXO1 [183]

Inflammaging: a new immunemetabolic viewpoint for age- related diseases

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In older adults, leaflets decrease in density, size, or both (Popov et al., 2023), reducing astrocytic interaction with synapses, limiting their homeostatic support, becoming less active in the elimination of excitatory synapses, facilitating the spillover of neurotransmitters, compromising neurotransmitter uptake and K + clearance (Popov et al., 2021), and affecting synaptic plasticity (Valtcheva and Venance, 2019