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Rarely, the cause of HC is not of primary thyroid origin, but is because of reduced TSH excretion by the pituitary gland (e.g., hypopituitarism) ( Patients presenting with secondary hypothyroidism have been previously submitted to surgery or radiotherapy because of pituitary adenoma, or are affected by pituitary macroadenoma overwhelming TSH-producing pituitary cells

doi: 10.1016/j.clnu.2018.08.009 20

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In addition, they participated in the regulation of the expression of Bax, Bcl2, caspase-3, and cytochrome, which are highly related to apoptosis, as well as promoting a positive regulation of p53, a key molecule involved in cell death ( Olea europaea L.) and bromelain could have promising effects against lung cancer ( The combination of curcumin, harpagophytum and bromelain has been shown to reduce inflammation and pain in osteoarthritic human synovial cells, through the decrease of prostaglandin E2, Nerve Growth Factor (NGF), IL-6 (148)