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Although several candidate drug resistance mechanisms, including impaired DNA repair, decreased drug uptake, increased drug efflux and detoxification, have been proposed (reviewed by Galluzzi et al, 2012), we are still some way from understanding the molecular basis of drug resistance, and from developing biomarkers to predict the onset and monitor the development of drug-resistant disease in cancer patients

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

doi: 10.1007/bf01803560 45 DavisS

They discovered that 94% of the 72 patients treated with temocillin and 99% of the 72 patients treated with a carbapenem achieved clinical remission (p = 0.206)

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At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)