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Oxidatively generated base modifications in DNA: not only carcinogenic risk factor but also regulatory mark

Novel AOMs, largely based around incretin therapy, may exceed weight loss of 20% [10, 75], however, most trials evaluating their efficacy and safety were performed with younger adults, and those that include older adults often poorly define the number of participants in each age group

Despite these promising findings, translating preclinical results into clinical practice has been hindered by challenges such as poor pharmacokinetics and significant side effects observed with classical inducers

This heme is utilized for the transcriptional regulation of HMOX1 (Sun et al., 2002), and heme catabolism releases iron, which acts in the translational regulation of key proteins involved in iron homeostasis [Rouault et al

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Common variants include: GSTM1 null : 40-50% of population-reduced capacity to neutralize environmental toxins GSTP1 variants : Impaired detoxification of carcinogens 6