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Some women continue having monthly bleeding, while others experience only occasional spotting or no bleeding at all

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Similarly, intestinal Zip8 KO mice exhibit systemic Mn deficiency and aggravated colitis, which can be rescued by inhibition of the downstream sphingolipid enzyme ACER1 (Choi et al., 2024b)

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Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y (2016) Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice

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In rat models of PAH induced by pulmonary artery banding or MCT, Wnt/-catenin activation enhances the mRNA and protein expression of periostin, CTGF, and COL3 by activating FOSL1 and FOSL2

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