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Eids watchful eye and coaching

Payers want to see that the prescriber is following the FDA-approved escalation protocol: starting at 2.5mg weekly for 4 weeks, then increasing to 5mg weekly, with subsequent increases as clinically indicated

Monoglutamate, but not polyglutamate forms are substrates to several folate-transporting proteins and are able to cross plasma membranes 275,876 or mitochondrial membranes 877,878