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The conversion of homocysteine to methionine requires the availability of choline or folic acid to provide methyl groups, so when folic acid is deficient, cells metabolize more choline, resulting in a deficiency of phosphatidylcholine, a key component of mycelin

Supplementary Figure 2 Dose responses of BAY11-7082 co-treated with peroxynitrite in cultured SGNs

(PubMed) Andersson M, Braegger CP

This subsequently induces apoptosis via two pathways: direct cleavage and activation of caspase-3 and caspase-7, or truncated BID, which links to the mitochondrial-mediated intrinsic apoptosis pathway (51)

Crit Rev Immunol 29(3):187201 Croft M, So T, Duan W, Soroosh P (2009) The significance of OX40 and OX40L to T-cell biology and immune disease