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It is well documented that this fluid flow contributes to the clearance of waste products from the brain 580

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The supernatant and cells were harvested for subsequent examination

In summary, these potentially novel Mmut p.L690Ins/p.L690Ins mice recapitulate many of the biochemical and clinical presentations of MMA seen in human patients, survive into adulthood, and can be rescued with gene therapy

In vivo yeast assays demonstrated that ChaC1 and its homologues promote growth on GSH by breaking it down into 5-oxoproline and cys-gly, a function lost in catalytic mutants