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It could be due to the injection missing the target

By day 15, IGF-2 levels in all groups had dropped to near-baseline and remained low through day 30

moreover, cancer risk reduction was more elevated in patients with the glutathione S-transferase theta 1 (GSTT1)-null genotype than the GSTT1-present carriers [67]

Individuals with genetic variants associated with reduced GST activity or impaired antioxidant enzyme function may require higher glutathione support or more frequent dosing schedules

Exosomes - vesicular carriers for intercellular communication

Such screening would follow or combine automated fractionation (LC-MS guided), reliable miniaturized persister assays, and orthogonal readouts (viability, metabolic reporters, single cell imaging) to limit false positives that inhibit or kill only growing cells (Petersen et al., 2024)