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Either Trx1 or Grx1 are required for each turnover of RNR, the essential enzyme for deoxyribonucleotides synthesis during DNA replication and repair

Lessons from epidermal patterning in Arabidopsis

Mitochondrial dysfunction leads to cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances and endothelial dysfunction, which all could play a role in long COVID

Future studies should focus on identifying its active constituents, elucidating detailed mechanisms of action, and validating its efficacy in well-designed clinical trials

At the same time, it downregulates the expression of multiple drug efflux pumps in tumor cells, thereby reversing multidrug resistance (MDR) and increasing the intracellular accumulation and cytotoxicity of chemotherapeutic agents such as cisplatin, paclitaxel, and 5-FU (Ghosh et al., 2022)

doi: 10.1016/j.rbmo.2019.12.005 57 ZhangHYangKChenFLiuQNiJCaoWet al