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In terms of iron metabolism, studies have found increased iron content in IBD intestinal tissues, higher levels of Fe2+ involved in the Fenton reaction of cellular ferroptosis, and significantly elevated mRNA and protein levels of FTL and FTH1

Alkynes and azides have taken a leading role in click chemistry, as they are common functional groups with a mild and chemoselective reactivity profile 7,8,9

Modulating antioxidant systems as a therapeutic approach to retinal degeneration

Combined effect is widely described as synergistic in preclinical and pharmacology literature

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas