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This entire process prevents the cell from producing misfolded or altered proteins.[ref] Studies show that high homocysteine levels cause ER stress and activate the unfolded protein response pathway, which can lead to cell death

The answer is short and simple: We dont know

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10.1097/00007632-199909010-00003 280 TamV.ChenP.YeeA.SolisN.KleinT.KudelkoM.et al (2020)

The t -test indicated a statistical difference between the two groups, confirming that GSH reserves are markedly depleted in hypoxic hepatic tissues [t 22 = 3.5, p = 0.003]