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Together, these results strongly suggested that the consumption of GSH is essential for enhancing CDDP chemosensitivity, which also explained the superior therapeutic effect of CDCZA nanoparticles in vitro

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Am J Physiol Heart Circ Physiol (1999) 276:H194350

8.2 Metabolism and elimination of curcumin Curcumins bioavailability in humans is mostly limited by poor intestinal absorption, rapid hepatic metabolism, and rapid systemic elimination, even at high doses of 12 g/day (104)