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Oral epithelial dysplasia and premalignancy

10.1038/414799a 6 AlekseyV

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NAFLD and liver transplantation: Current burden and expected challenges

Upon binding to cytoplasmic glucocorticoid receptors (GR), corticosteroids induce translocation of GR complexes into the nucleus, where they interact with glucocorticoid response elements (GREs) to upregulate anti-inflammatory genes (e.g., IL-10, DUSP-1) and suppress pro-inflammatory mediators like IL-1, IL-6, TNF-, and chemokines, such as MCP-1 and IL-8 (McManus 2003