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The tradeoff is bioavailability

26- Bennett M

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Optimize these variables for maximum benefit

Adverse Reactions/Side Effects The following clinically significant adverse drug reactions are described elsewhere in the labeling: Drugs with Same Active Ingredient [see Warnings and Precautions (5.1)] Hypocalcemia and Mineral Metabolism [see Warnings and Precautions (5.2)] Renal Impairment [see Warnings and Precautions (5.3)] Osteonecrosis of the Jaw [see Warnings and Precautions (5.4)] Atypical Fractures Including Femoral Fractures [see Warnings and Precautions (5.5)] Musculoskeletal Pain [see Warnings and Precautions (5.6)] Patients with Asthma [see Warnings and Precautions (5.7)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

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