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3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

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Technical Characteristics Compound name: HGH Frag 176-191 Type: Synthetic peptide fragment Origin: Human growth hormone fragment (amino acids 176191) Form: Lyophilized powder Purity: 98% Regulatory status: Research Use Only (RUO) Classification: Not intended for clinical, therapeutic, or diagnostic use Each batch undergoes rigorous quality control to ensure identity, purity, and consistency for scientific research applications

Perspectives on new synthetic curcumin analogs and their potential anticancer properties

doi: 10.1590/S0100-879X2005000700003