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Further research is needed to clarify how these differences translate into clinical safety and efficacy.16 Pharmacokinetics and pharmacodynamics The area under the plasma concentrationtime curve (AUC) and maximum plasma concentration (Cmax) of ritlecitinib increase approximately proportionally with dose up to 200mg, with a terminal half-life ranging from 1.3 to 2.3h

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Although no significant difference was detected in its primary endpoint, more patients reported improvement in fatigue in the anakinra group compared with the placebo group (Table I) [66]

jin, L., A., G