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[2] That work reported a long half-life on the order of 159195 hours (about 78 days) consistent with once-weekly dosing, and it provided the first human safety and tolerability read on the cagrilintide-plus-incretin concept that later became CagriSema

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As with all investigational medicines, the safety profiles of cagrilintide and retatrutide are still being characterised through ongoing clinical trials