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Transl Res (2022) 245:3040

Why This Happens The passenger protein is intrinsically aggregation-prone : The fusion partner was masking the problem, not solving it Concentration effect : After cleavage and reverse purification, the passenger is more concentrated Removal of chaperone effect : The fusion partner was actively stabilizing the passenger's folded state How Common Is It

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The gut as the motor of multiple organ dysfunction in critical illness

During the AA stimulation, the H 2 O 2 concentration in single-culture culture increases in a faster pace and reaches to a higher value comparing to that in spheroid culture