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To confirm this finding, we carried out ChIP-qPCR using anti BRD4 and anti H3K4me3 antibodies in acute myeloid leukemia Kasumi-1 and chronic myelogenous leukemia K562 cell lines, characterized by the presence of endogenous ASXL1 1-645 and ASXL1 1-591 truncation variants, respectively

FK866 was again administered at a low dose (0.5 mg/Kg) to aged mouse models over four weeks, leading to significant improvements in cognitive function and locomotor activity

Ritter Birgit, Greten Florian R

Khoshbaten M, Aliasgarzadeh A, Masnadi K, et al

10.1016/j.bbagen.2009.05.010 BBA Gen

Overall, our data demonstrate that a ketogenic diet can effectively normalize blood glucose levels in streptozotocin-treated mice with hyperglycemia