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The antioxidant enzyme catalyzes the reduction of hydrogen peroxide and hydroperoxides formed from fatty acids, thereby effectively removing toxic peroxides from living cells

Additionally, other ABC transporters like ABCB4, ABCG4, and ABCG6 contribute to this resistance by enhancing drug efflux (Prez-Victoria et al., 2011

These findings suggest that ferroptosis can lead to IEC damage/disruption

The absence of functional CFTR disrupts epithelial water and ion homeostasis, leading to the accumulation of dehydrated mucus, recurrent bacterial infections, and ultimately organ failure and other life-threatening consequences [78]

In a murine model of alkali-induced corneal injury, Fer-1 administration significantly reduced corneal opacity and abnormal neovascularization

doi: 10.1016/j.molmed.2010.09.003