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Front Endocrinol (Lausanne) 16:1537208

Yang F, Lim GP, Begum AN et al (2005) Curcumin inhibits formation of amyloid oligomers and fibrils, binds plaques, and reduces amyloid in vivo

Direct mechanisms involve the immediate neutralization of ROS through the donation of electrons or hydrogen, resulting in the formation of stable, non-toxic compounds [37]

Despite the variety of mechanisms through which current drugs operate, most approved treatments fail to prevent the pathological progression of AD, and often exhibit limited efficacy or notable side effects (12,13)