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Exendin-4, an agonist of the glucagon-like peptide GLP-1 receptor (GLP-1R), interacts with most of these intracellular proteins and factors further supporting the idea that autophagy is implicated in T2DM pathogenesis (Masini et al., 2009)

Rats were observed for one week before the experiment started to allow for adaptation

By contrast, females showed more genotype-dependent metabolic variations, predominantly involving lipid, betaine, methionine, energy and one-carbon metabolism pathways, indicating greater heterogeneity across variants

de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD

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Bianchi M, Hakkim A, Brinkmann V, Siler U, Seger RA, Zychlinsky A, Reichenbach J (2009) Restoration of NET formation by gene therapy in CGD controls aspergillosis