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Hou demonstrated that autophagy induces ferroptosis through the degradation of ferritin in fibroblasts and cancer cells ( 3.1.2 ROS imbalance plays an important role in ferroptosis Lipid peroxidation is the fundamental root cause of ferroptosis, and since lipids make up the majority of cell membranes, they are also the dominating targets of ROS

The responses of NAPstar sensors remained largely stable across various pool sizes, indicating a predominant sensitivity to the NADP redox state rather than the individual concentrations of NADPH or NADP +