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#5 Headaches (low to moderate risk) Headaches or migraines can be triggered, especially in sensitive individuals

The sustained high levels of ROS induce meiotic cell cycle arrest and apoptosis in follicular oocytes[15,61,62]

Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell proliferation

Supporting this interpretation, a previous clinical study reported that individuals carrying SNPs associated with reduced GLUT2 expression exhibit greater responsiveness to metformin, further suggesting that decreased intestinal glucose absorption mediated by reduced expression of glucose transporters such as GLUT2 may play an important role in enhancing overall glucose homeostasis after metformin administration 52

Its clinical efficacy is recognized, and it often serves as a control standard when evaluating novel therapies (Mazurek et al., 2025)

Supplementary Figure 5 Volcano plot of differentially expressed genes following cold acclimation