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Colorectal cancer metastatic dMMR immunotherapy (COMMIT) study: A randomized phase III study of atezolizumab (atezo) monotherapy versus mFOLFOX6/bevacizumab/atezo in the first-line treatment of patients with deficient DNA mismatch repair (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer 9NRG-GI004/SWOG-S1610)

Activated NLRP3 binds to an adapter proteinASC, which contains a caspase-recruitment domainfacilitating the aggregation of ASC into stable filamentous structures

[27],[28] Psychodermatological conditions Trichotillomania Trichotillomania is an abnormal habit and impulse control disorder characterized by a sense of tension immediately before pulling hair or when trying to resist pulling and relief of this tension after hair pulling