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established a chemotherapy-induced neurotoxicity in vitro model using induced pluripotent stem cells differentiated into neurons (Wheeler et al., 2015

3 Lipid peroxidation in cancer: a double-edged sword 3.1 Biochemical pathways of lipid peroxidation and the role of ROS-lipid interaction Lipid peroxidation is a process that occurs when reactive oxygen species (ROS) are produced during the spontaneous oxidation of lipids, particularly in polyunsaturated fatty acids (PUFAs) [46, 47]

0.16 ng/ml/12 ml/day till the sacrifice) and intragastrically after cuprizone instilations, while controls received simultaneously drinking water only (12 ml/day) as well as an equivolume of saline (5 ml/kg) intragastrically after cuprizone instillations