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The samples were digested sequentially, first using Lys-C alone and then adding additionally porcine trypsin

10.1248/bpb.32.651 Biol

Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles

doi: 10.1016/j.autrev.2008.08.003 228 HornigMGottschalkGPetersonDLKnoxKKSchultzAFEddyMLet al

HCQ-induced cardiac toxicity after high oral doses was remarkable, while no cardiac adverse effect or significant electrocardiogram (ECG) changes were reported after administration of nebulized inhaled HCQ simple solution to healthy volunteers with 40-fold lower dose for COVID-19 treatment [43]

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