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Cells were cultured in 24 well plates and treated with GHK or GHKPEG at 1, 5 and 10 nM for 24, 48 or 72 hr

Nrf2 is a key transcription factor with a basic-region leucine zipper (bZIP) structure in the Cap-n-Collar (CNC) family, which controls many aspects of cell homeostasis in response to oxidative stress and toxic insults in various tissues and cells (Skibinski et al., 2017

Our methylene blue is a 1% aqueous solution used as a synthetic dye for dyeing fibers such as cotton, silk, and paper

Non-leafy vegetables retain more folate during their boiling than do leafy ones 379,386,393

For clinicians , this means opportunity: CKD management becomes proactive, integrative, and personalized not just managing decline, but actively working to stabilize or even improve kidney health

Additionally, polyphenols interact with other neurotransmitter systems, including dopamine and noradrenaline, which play crucial roles in motivation, pleasure, and cognitive function [215, 216]