glutathione tumor A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview A glutathione-depleting chemodynamic therapy agent

For comparisons among three or more independent groups, one-way analysis of variance (ANOVA) followed by Tukeys multiple comparisons test was applied when variances were equal, whereas Welchs ANOVA with Dunnetts T3 post-hoc test was used when variances were unequal

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As lipid peroxidation is a defining characteristic of ferroptosis, we carried out untargeted lipidomics analysis in SK-MEL-103 cells undergoing etoposide or tozasertib-induced senescence (Fig

During nutrient deprivation and autophagy, free FAs released from membranes are re-esterified into TAGs by DGAT1 and stored in LDs, thereby preventing a sudden influx of FAs into mitochondria that would otherwise overload the electron transport chain and trigger excessive reactive oxygen species (ROS) production 29,85

Supporting healthy homocysteine levels with 5-MTHF, methylcobalamin, and B vitamins removes one of the two primary calcium inputs

The role of current techniques and concepts in peripheral nerve repair