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The challenges of these technologies include high costs, complex data analysis, and the need for validation in large-scale samples

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They should also talk with a doctor before using suppositories if they: have had recent rectal surgery, prostate surgery, or vaginal treatment have an irregular heartbeat Although they may be unpleasant to use, rectal and vaginal suppositories can be an effective way of delivering medication.

( Reference Birkenfeld, Kluge and Eder 91 )