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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

doi: 10.6133/apjcn.2016.25.1.04

Currently valid German guidelines for RLS (without comorbid PD) treatment [91] recommend a work-up of iron metabolism, aiming at high normal serum levels of ferritine and transferrin saturation

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