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To determine the effects of stimulating TCA cycle activity, we treated hepatocytes with dichloroacetate (DCA), which stimulates substrate entry into the TCA cycle by inhibiting PDKs (Constantin-Teodosiu et al., 1999, Wu et al., 2018)

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doi: 10.1016/j.mad.2015.01.003

As with live bacterial diet, a higher concentration of NAC further exacerbated its negative effect on the lifespan (Fig

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Umgeht die vorgelagerte endokrine Stimulation: Im Gegensatz zu Peptiden, die die Freisetzung von Wachstumshormon stimulieren, ist IGF-1 LR3 nicht von einer Aktivierung der Hypophyse abhngig