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The presence of age-related spots may be attributed to local changes in fibroblast architecture, where the number and growth of fibroblasts decrease along with their secretory activity as one ages (143)

The relationship between age, gender, BMI, diet, salivary pH and periodontal pathogenic bacteria in children and adolescents: a cross-sectional study

The results showed that biochemical processes related to energy metabolism, such as NADH metabolism and glycolysis through glucose-6-phosphate, as well as DNA replication checkpoint signaling involved in DNA replication and repair, were significantly enriched at both the PreNAC and PostNAC time points (Fig