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Most common causes of the discolouration include: Medications amino-salicyclic acid derivatives mesalazine/paraaminosalycylic acid/sulfasalazine doxorubicin , hydroxocobalamin , ibuprofen, phenothiazines, phenolphthalein, propofol , rifampicin/rifampin Dietary ingestants beeturia , rhubarb, blackberries, food dyes Metabolic abnormalities porphyria , urate crystals Hydroxocobalamin Early features of cyanide poisoning include nausea, vomiting, headache, dyspnoea, tachypnoea, hypertension, tachycardia, collapse and seizures

However, this study lacked a control group or placebo comparison, and the sample size was very small

Table 7: Bleeding ain Deep Vein Thrombosis and Pulmonary Embolism Treatment Studies a Bleeding rates are during the study drug treatment period (approximately 7 days)

For deep structural wrinkles, GHK-Cu's dermal action may be more direct