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Medically, glutathione is critical because it: Functions as a cofactor for many enzymatic reactions, including those involved in detoxification and free radical neutralization Plays a key role in Phase II liver detoxification the stage of detox where the liver makes toxins water-soluble so they can be safely excreted through urine or bile (see liver detox pathway below) Helps regenerate other antioxidants such as vitamin C and vitamin E, maintaining balance in the bodys antioxidant network Supports immune regulation by influencing lymphocyte function and modulating inflammatory pathways Liver Detox Pathway Further Explained: Phase I Phase II Excretion Phase I: The liver starts breaking down toxins (sometimes creating more reactive byproducts)

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[49] took an alternative approach to serum analysis by investigating pancreatic ductal fluid, which, unlike serum, requires an endoscopic procedure for collection

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Methods We searched PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov until August 31, 2023

For example, a randomized controlled trial (RCT) found that applying curcumin gel into periodontal pockets after SRP significantly reduced probing depth and gingival inflammation, and lowered IL-1 in crevicular fluid compared to SRP alone (Mohammad, 2020)