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The body weight, living status, and tumor size of the nude mice were recorded

For parthanatos, DNA damage caused by mitochondrial impairment activates poly(ADP-ribose) polymerase 1 (PARP1), and excessive production of poly(ADP-ribose) (PAR) leads to NAD+ depletion and mitochondrial function collapse, ultimately inducing parthanatos [42]

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Preclinical studies involving 5-Amino-1MQ have explored its effects on body composition, adipocyte metabolism, glucose regulation, and energy expenditure

A.MagdyM.IsmailA.AttiaA.AhmedH.et al

Zhu DM, Zhao WM, Cui SS, et al