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Interestingly, the shorter peptide gH493-512, corresponding only to the N-terminus of gH493-537, effectively inhibited HSV entry with approximately 60% inhibition observed at 250 mM and 90% inhibition at 500 mM

Sandry et al., 2021)

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This attack results in the reduction of the protein substrate and the formation of a mixed disulfide bond between the N-terminal cysteine residue of the Grx-S-SG

Consequently, when system Xc is inhibited, the diversion pathway can counteract ferroptosis resulting from system Xc inhibition [146]

This proposed roundtable session draws on lessons from multiple European Commission funded DT research projects from across Europe including BIPED (Building Intelligent Positive Energy Districts), TIPS4PED and Twin4Resilience