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Different methods have been employed for their synthesis, such as chemical oxidation, microwave-assisted synthesis, laser ablation, atmospheric plasma-based synthesis, thermolysis, hydrothermal carbonization, solvothermal, electrochemical, and ultrasonic methods

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Recently, it was also found that plant extracts can regulate microglia to express the M2 phenotype more than the M1 phenotype (Yang et al., 2017) to reduce neuroinflammation and nerve cell damage and to clear A (Figure 2)

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