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Gkika, N

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doi: 10.1038/ajg.2012.219

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dos Santos AF, Fazeli G, Xavier da Silva TN, Friedmann Angeli JP

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For instance, in tumors harboring p53 72P variant, PSAT1 interacts competitively with the mutant without relying on its enzymatic function, promoting the nuclear import of peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) and thereby increasing mitochondrial biogenesis, oxidative phosphorylation (OXPHOS), and TCA cycle processes (Fig

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